Active chiral metasurfaces enable continuous on-chip polarization engineering, detection and encoding. Here, we introduce a facile bottom-up approach that produces circular dichroism of up to 11 degrees in the visible-near-infrared spectral region. This pronounced effect surpasses previous colloidal approaches by two orders of magnitude. Furthermore, the presented design of stacked particle chain arrays allows in-situ re-stacking and local compression to tune dynamically all aspects of circular dichroism: sign, magnitude and spectral position.