A survey of practice patterns for adaptive particle therapy for interfractional changes

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Petra Trnkova - , Medizinische Universität Wien (Autor:in)
  • Ye Zhang - , Paul Scherrer Institute (Autor:in)
  • Toshiyuki Toshito - , Nagoya City University (Autor:in)
  • Ben Heijmen - , Erasmus University Rotterdam (Autor:in)
  • Christian Richter - , OncoRay ZIC - Nationales Zentrum für Strahlenforschung in der Onkologie (Partner/Träger: UKD, HZDR), Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf (Autor:in)
  • Marianne C. Aznar - , University of Manchester (Autor:in)
  • Francesca Albertini - , Paul Scherrer Institute (Autor:in)
  • Alessandra Bolsi - , Paul Scherrer Institute (Autor:in)
  • Juliane Daartz - , Harvard University (Autor:in)
  • Antje C. Knopf - , Paul Scherrer Institute, Fachhochschule Nordwestschweiz (Autor:in)
  • Jenny Bertholet - , Universität Bern (Autor:in)

Abstract

Background and purpose: Anatomical changes may compromise the planned target coverage and organs-at-risk dose in particle therapy. This study reports on the practice patterns for adaptive particle therapy (APT) to evaluate current clinical practice and wishes and barriers to further implementation. Materials and methods: An institutional questionnaire was distributed to PT centres worldwide (7/2020–6/2021) asking which type of APT was used, details of the workflow, and what the wishes and barriers to implementation were. Seventy centres from 17 countries participated. A three-round Delphi consensus analysis (10/2022) among the authors followed to define recommendations on required actions and future vision. Results: Out of the 68 clinically operational centres, 84% were users of APT for at least one treatment site with head and neck being most common. APT was mostly performed offline with only two online APT users (plan-library). No centre used online daily re-planning. Daily 3D imaging was used for APT by 19% of users. Sixty-eight percent of users had plans to increase their use or change their technique for APT. The main barrier was “lack of integrated and efficient workflows”. Automation and speed, reliable dose deformation for dose accumulation and higher quality of in-room volumetric imaging were identified as the most urgent task for clinical implementation of online daily APT. Conclusion: Offline APT was implemented by the majority of PT centres. Joint efforts between industry research and clinics are needed to translate innovations into efficient and clinically feasible workflows for broad-scale implementation of online APT.

Details

OriginalspracheEnglisch
Aufsatznummer100442
FachzeitschriftPhysics and imaging in radiation oncology
Jahrgang26
PublikationsstatusVeröffentlicht - Apr. 2023
Peer-Review-StatusJa

Externe IDs

ORCID /0000-0003-4261-4214/work/146644857

Schlagworte

Schlagwörter

  • Adaptive radiotherapy (ART), Adaptive treatment planning, Image guided particle therapy, Interfraction anatomical variation, Particle/proton therapy