A review of the clinical introduction of 4D particle therapy research concepts

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

  • Barbara Knäusl - , Medizinische Universität Wien (Autor:in)
  • Gabriele Belotti - , Polytechnic University of Milan (Autor:in)
  • Jenny Bertholet - , Universität Bern (Autor:in)
  • Juliane Daartz - , Massachusetts General Hospital (Autor:in)
  • Stella Flampouri - , Emory University (Autor:in)
  • Mischa Hoogeman - , HollandPTC, Erasmus University Rotterdam (Autor:in)
  • Antje C. Knopf - , Fachhochschule Nordwestschweiz (Autor:in)
  • Haibo Lin - , New York Proton Center (Autor:in)
  • Astrid Moerman - , HollandPTC (Autor:in)
  • Chiara Paganelli - , Polytechnic University of Milan (Autor:in)
  • Antoni Rucinski - , Polska Akademia Nauk (Autor:in)
  • Reinhard Schulte - , Loma Linda University Health (Autor:in)
  • Shing Shimizu - , Osaka University (Autor:in)
  • Kristin Stützer - , Universitätsklinikum Carl Gustav Carus Dresden, Helmholtz-Zentrum Dresden-Rossendorf (HZDR) (Autor:in)
  • Xiaodong Zhang - , University of Texas MD Anderson Cancer Center (Autor:in)
  • Ye Zhang - , Paul Scherrer Institute (Autor:in)
  • Katarzyna Czerska - , Paul Scherrer Institute (Autor:in)

Abstract

Background and purpose: Many 4D particle therapy research concepts have been recently translated into clinics, however, remaining substantial differences depend on the indication and institute-related aspects. This work aims to summarise current state-of-the-art 4D particle therapy technology and outline a roadmap for future research and developments. Material and methods: This review focused on the clinical implementation of 4D approaches for imaging, treatment planning, delivery and evaluation based on the 2021 and 2022 4D Treatment Workshops for Particle Therapy as well as a review of the most recent surveys, guidelines and scientific papers dedicated to this topic. Results: Available technological capabilities for motion surveillance and compensation determined the course of each 4D particle treatment. 4D motion management, delivery techniques and strategies including imaging were diverse and depended on many factors. These included aspects of motion amplitude, tumour location, as well as accelerator technology driving the necessity of centre-specific dosimetric validation. Novel methodologies for X-ray based image processing and MRI for real-time tumour tracking and motion management were shown to have a large potential for online and offline adaptation schemes compensating for potential anatomical changes over the treatment course. The latest research developments were dominated by particle imaging, artificial intelligence methods and FLASH adding another level of complexity but also opportunities in the context of 4D treatments. Conclusion: This review showed that the rapid technological advances in radiation oncology together with the available intrafractional motion management and adaptive strategies paved the way towards clinical implementation.

Details

OriginalspracheEnglisch
Aufsatznummer100535
FachzeitschriftPhysics and imaging in radiation oncology
Jahrgang29
PublikationsstatusVeröffentlicht - Jan. 2024
Peer-Review-StatusJa

Schlagworte

Schlagwörter

  • 4D dose reconstruction, 4D imaging, 4D Treatment Workshop for Particle Therapy, Adaptive workflows, Intrafractional motion, Motion management, Particle therapy