3D Bioprinting tissue analogs: Current development and translational implications

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung


  • Suihong Liu - , Zentrum für Translationale Knochen-, Gelenk- und Weichgewebeforschung (Autor:in)
  • Lijia Cheng - , Chengdu University (Autor:in)
  • Yakui Liu - , Zentrum für Translationale Knochen-, Gelenk- und Weichgewebeforschung (Autor:in)
  • Haiguang Zhang - , Shanghai Jiao Tong University (Autor:in)
  • Yongteng Song - , Shanghai Jiao Tong University (Autor:in)
  • Jeong-Hui Park - , Dankook University (Autor:in)
  • Khandmaa Dashnyam - , Dankook University (Autor:in)
  • Jung-Hwan Lee - , Dankook University (Autor:in)
  • Fouad Al-Hakim Khalak - , University of the Basque Country (Autor:in)
  • Oliver Riester - , University of Applied Sciences Furtwangen (Autor:in)
  • Zheng Shi - , Chengdu University (Autor:in)
  • Serge Ostrovidov - , Tokyo Medical and Dental University (Autor:in)
  • Hirokazu Kaji - , Tokyo Medical and Dental University (Autor:in)
  • Hans-Peter Deigner - , University of Applied Sciences Furtwangen (Autor:in)
  • José Luis Pedraz - , University of the Basque Country (Autor:in)
  • Jonathan C Knowles - , Dankook University (Autor:in)
  • Qingxi Hu - , Shanghai Jiao Tong University (Autor:in)
  • Hae-Won Kim - , Dankook University (Autor:in)
  • Murugan Ramalingam - , Chengdu University (Autor:in)


Three-dimensional (3D) bioprinting is a promising and rapidly evolving technology in the field of additive manufacturing. It enables the fabrication of living cellular constructs with complex architectures that are suitable for various biomedical applications, such as tissue engineering, disease modeling, drug screening, and precision regenerative medicine. The ultimate goal of bioprinting is to produce stable, anatomically-shaped, human-scale functional organs or tissue substitutes that can be implanted. Although various bioprinting techniques have emerged to develop customized tissue-engineering substitutes over the past decade, several challenges remain in fabricating volumetric tissue constructs with complex shapes and sizes and translating the printed products into clinical practice. Thus, it is crucial to develop a successful strategy for translating research outputs into clinical practice to address the current organ and tissue crises and improve patients' quality of life. This review article discusses the challenges of the existing bioprinting processes in preparing clinically relevant tissue substitutes. It further reviews various strategies and technical feasibility to overcome the challenges that limit the fabrication of volumetric biological constructs and their translational implications. Additionally, the article highlights exciting technological advances in the 3D bioprinting of anatomically shaped tissue substitutes and suggests future research and development directions. This review aims to provide readers with insight into the state-of-the-art 3D bioprinting techniques as powerful tools in engineering functional tissues and organs.


Seiten (von - bis)20417314231187113
FachzeitschriftJournal of tissue engineering : JTE
PublikationsstatusVeröffentlicht - Juli 2023

Externe IDs

PubMedCentral PMC10350769
Scopus 85164926764
WOS 001027983800001
Mendeley d9721674-09fc-35c2-affe-57b12c776702


Ziele für nachhaltige Entwicklung


  • 3D bioprinting, clinical translation, organ engineering, tissue analogs, volumetric biological structures, Tissue analogs, Clinical translation, Volumetric biological structures, Organ engineering