Strukturelle Bioinformatik (FoG)
Organisation: Forschungs-/Arbeitsgruppe
Organisationsprofil
Our group develops and applies computational strategies appplied to rational engineering and de novo design for target/drug discovery and biotechnology innovation.
By applying structure-based computational methods, molecular modeling and computer simulation techniques, and in very close collaboration with experimentalists, we try to decipher the relationships between biomolecular structure and function in order to understand the molecular basis of protein/DNA/other recognition, which will allow us to rationally intervene their biological function. Our current research focuses on the discovery and functional characterization of novel proteins, the rational engineering of proteins with improved functional properties, and de novo design of molecular scaffolds for a variety of biotechnological and biomedical applications.
Kontakt
Übergeordnete Einrichtungen
Schlagworte
Forschungsschwerpunkte
- The main goal of the group is the identification, characterization and engineering of therapeutically/biotechnologically interesting targets and to understand and engineer biological systems.
- Protein engineering and rational ligand design
- Molecular recognition
- Integrative bioinformatics
- Protein structure and function relationships