Prediction of the effect of dry air on the skin by coupling building simulation, indoor air flow and person model. An AmI platform concept (AmI = Ambient Intelligence) was developed on the basis of an integrated building simulation in conjunction with a person model in order to better map the effects of humidity on the indoor climate. For this purpose, a wide range of investigations of indoor climate situations in offices of varying degrees of detail were carried out on the basis of coupled building, system and indoor air flow simulations. The simulation model was also extended to include a person model, which generates an evaporation rate via the skin from room climate conditions. At the same time, extensive subject tests were carried out at the German Federal Institute for Occupational Safety and Health (BAuA) in Dortmund to experimentally determine the evaporation rates in a climate chamber specially designed for this purpose. The proband tests were conducted in two series and a total of 380 data sets were generated for two different room temperatures, ventilation types and relative humidities. The results were presented in detail, evaluated and compared with the data from the further developed, innovative simulation model for calculating building, system and room air flow, including a person model.