Stability of lipid domains

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Ana J. García-Sáez - , TUD Dresden University of Technology (Author)
  • Petra Schwille - , Chair of Biophysics (Author)

Abstract

Membranes with simple lipid composition exhibit complex phase behavior. Ordered and disordered liquid phases can coexist in cholesterol-containing membranes with lipid compositions resembling biological membranes and at physiological temperatures. Research during the last years suggests that these lipid domains play a role in the organization of biological membranes. Understanding the principles that govern the formation and stability of lipid domains is of great importance to build a model that properly describes membrane structure and function. In this review, we describe the current knowledge of the chemical and physical basis of lipid domains and its application to biological membranes.

Details

Original languageEnglish
Pages (from-to)1653-1658
Number of pages6
JournalFEBS letters
Volume584
Issue number9
Publication statusPublished - May 2010
Peer-reviewedYes

External IDs

PubMed 20036662

Keywords

Keywords

  • Cholesterol, Line tension, Lipid-lipid interaction, Liquid ordered phase, Sphingolipid