Soluble Neuropilin-1 is an independent marker of poor prognosis in early breast cancer

Research output: Contribution to journalResearch articleContributedpeer-review



BACKGROUND: Neuropilin-1 (NRP-1) is a transmembrane protein that acts as a multifunctional non-tyrosine kinase receptor with an established role in development and immunity. NRP-1 also regulates tumor biology, and high expression levels of tissue NRP-1 have been associated with a poor prognosis. Recently, ELISA-based quantification of soluble NRP-1 (sNRP-1) has become available, but little is known about the prognostic value of sNRP-1 in malignancies.

MATERIALS AND METHODS: We measured sNRP-1 in the serum of 509 patients with primary early breast cancer (BC) at the time of diagnosis using ELISA.

RESULTS: Mean serum values of sNRP-1 were 1.88 ± 0.52 nmol/l (= 130.83 ± 36.24 ng/ml). SNRP-1 levels weakly correlated with age, and were higher in peri- and postmenopausal patients compared to premenopausal patients, respectively (p < 0.0001). Low levels of sNRP-1 were associated with a significant survival benefit compared to high sNRP-1 levels at baseline (p = 0.005; HR 1.94; 95%CI 1.23-3.06). These findings remained significant after adjustment for tumor stage including lymph node involvement, grading, hormone receptor, HER2 status, and age (p = 0.022; HR 1.78; 95%CI 1.09-2.91).

CONCLUSION: Our findings warrant further investigations into the prognostic and therapeutic potential of sNRP-1 in BC.


Original languageEnglish
Pages (from-to)2233-2238
Number of pages6
JournalJournal of cancer research and clinical oncology
Issue number8
Publication statusPublished - Aug 2021

External IDs

PubMedCentral PMC8236462
Scopus 85104974691
ORCID /0000-0003-3717-3637/work/141545160
ORCID /0000-0002-8691-8423/work/142236035


Sustainable Development Goals


  • Adult, Aged, Aged, 80 and over, Biomarkers, Tumor/blood, Breast Neoplasms/blood, Cohort Studies, Disease Progression, Early Diagnosis, Female, Humans, Middle Aged, Neoplasm Staging, Neuropilin-1/blood, Prognosis, Retrospective Studies, Solubility