Septische Granulomatose als seltene Differenzialdiagnose rezidivierender pulmonaler Infektionen bei Erwachsenen
Research output: Contribution to journal › Research article › Contributed
Contributors
Abstract
Chronic granulomatous disease (CGD) should be considered as a differential diagnosis in children and adolescents with frequent infections, especially when caused by certain specific pathogens.This case report describes a 64-year-old female with multiple recurrent and complicated bronchopulmonary infections, caused by common, but also rare pathogens, autoimmune phenomena, malignancies and recurrent organizing pneumonia (OP) with granulomas. Finally, the patient was diagnosed with p47phox-deficient chronic granulomatous disease (CGD).Individuals with a primary immunodeficiency may survive multiple complications and may be diagnosed at an advanced age especially if the affected structure shows residual activity. When confronted with patients with recurrent bronchopulmonary infections, especially with certain specific rare pathogens, in combination with organizing pulmonary granulomas as well as autoimmune phenomena, CGD should be considered even in elderly patients. Delayed diagnosis significantly increases mortality and morbidity in such cases.
Translated title of the contribution | Chronic Granulomatous Disease A Rare Differential Diagnosis in Recurrent Pulmonary Infections in Adults |
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Details
Original language | German |
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Pages (from-to) | 678-683 |
Number of pages | 6 |
Journal | Pneumologie |
Volume | 74 |
Issue number | 10 |
Publication status | Published - Oct 2020 |
Peer-reviewed | No |
External IDs
ORCID | /0000-0001-6022-6827/work/127321412 |
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Scopus | 85088129468 |
ORCID | /0009-0003-6519-0482/work/143074879 |
Keywords
Keywords
- Diagnosis, Differential, Female, Granulomatous Disease, Chronic/complications, Humans, Infections, Middle Aged, Pneumonia/diagnosis