Background: Individual financial distress (FD) of a cancer disease impacts patient's health-related quality of life. FD also occurs in countries with universal healthcare coverage, but comprehensive data about the extent is lacking. We have developed a new standardized PROM for FD in Germany based on qualitative pre-studies (patients/social services representatives) and a literature review. The validity of the PROM is tested in two survey waves including at least n=400 cancer patients. This study aims to determine the degree of FD in cancer patients using the PROM. Method(s): A bi-centered cross-sectional study was performed including n=112 cancer patients; the PROM was administered between June/ July 2022 in outpatient units, ambulances or oncological wards of two university hospitals in Germany. Patients were eligible if they had confirmed solid cancer (ECOG-Status 2 months of therapy. A MANOVA was performed to analyze the dimensions of FD. Result(s): 88.3 percent of patients reported higher (non-)medical costs due to cancer disease in the last six month, spending on average 400 per month. 65.1 percent of patients experienced a loss of income (p