Feasibility and effects of an online multimodal mind–body intervention on mental and physical well-being in older adults: The REMINDer randomized controlled study

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Selina Stamer - , University Medicine (Faculty of Medicine and University Hospital), German Center for Neurodegenerative Diseases (DZNE) - Partner Site Dresden (Author)
  • Adrianna Lipska-Dieck - , German Center for Neurodegenerative Diseases (DZNE) - Partner Site Dresden (Author)
  • Maxie Luft - , German Center for Neurodegenerative Diseases (DZNE) - Partner Site Dresden (Author)
  • Karla Paola Reif - , German Center for Neurodegenerative Diseases (DZNE) - Partner Site Dresden (Author)
  • Sabine C. Koch - , Alanus University of Arts and Social Sciences Alfter, SRH University of Applied Sciences Heidelberg, University of Melbourne (Author)
  • René Mauer - , Institute for Medical Informatics and Biometry (Author)
  • Olga Klimecki - , University of Innsbruck (Author)
  • Miranka Wirth - , German Center for Neurodegenerative Diseases (DZNE) - Partner Site Dresden (Author)

Abstract

INTRODUCTION
Aging populations require scalable, accessible, and inclusive lifestyle interventions that address multiple modifiable dementia risk factors.

METHODS
The REMINDer pilot randomized controlled trial, randomized (1:1) healthy older adults (≥ 60 years, retired) to a 6-week online multimodal mind–body group intervention or a delayed-intervention control group. The live-streamed, home-based, two 1-hour sessions/week program integrates music, dance movement, and mindfulness via video conferencing. Primary outcomes were feasibility (adherence benchmark: ≥ 60%) and changes in mental and physical well-being (Health-Survey SF-12). Secondary outcomes comprised feasibility metrics and safety.

RESULTS
Intention-to-treat analyses included 68 participants (mean [standard deviaton {SD}] age: 69.2 [5.2] years; 80.9% women). Mean (SD) adherence was 80% (30%), exceeding the predefined benchmark (p = 0.010). There were no group differences in SF-12 mental (p = 0.827) or physical well-being (p = 0.656) from pre-to-post intervention. Feasibility was high, with 95% reach, 90% retention, and 9% dropout. No serious adverse events occurred.

DISCUSSION
The scalable, accessible online multimodal intervention is feasible and safe for older adults.

TRIAL REGISTRATION
ClinicalTrials.gov (Identifier: NCT06530277) on July 27, 2024. https://clinicaltrials.gov/study/NCT06530277.

Details

Original languageEnglish
Article numbere70071
Number of pages18
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume2
Issue number1
Publication statusPublished - 20 Mar 2026
Peer-reviewedYes

External IDs

ORCID /0009-0000-6060-6782/work/212492005

Keywords