Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay disease progression, type 1 diabetes screening programmes are being increasingly emphasised. Once broadly implemented, screening initiatives will identify significant numbers of islet autoantibody-positive (IAb+) children and adults who are at risk of (confirmed single IAb+) or living with (multiple IAb+) early-stage (stage 1 and stage 2) type 1 diabetes. These individuals will need monitoring for disease progression; much of this care will happen in non-specialised settings. To inform this monitoring, JDRF in conjunction with international experts and societies developed consensus guidance. Broad advice from this guidance includes the following: (1) partnerships should be fostered between endocrinologists and primary-care providers to care for people who are IAb+; (2) when people who are IAb+ are initially identified there is a need for confirmation using a second sample; (3) single IAb+ individuals are at lower risk of progression than multiple IAb+ individuals; (4) individuals with early-stage type 1 diabetes should have periodic medical monitoring, including regular assessments of glucose levels, regular education about symptoms of diabetes and DKA, and psychosocial support; (5) interested people with stage 2 type 1 diabetes should be offered trial participation or approved therapies; and (6) all health professionals involved in monitoring and care of individuals with type 1 diabetes have a responsibility to provide education. The guidance also emphasises significant unmet needs for further research on early-stage type 1 diabetes to increase the rigour of future recommendations and inform clinical care. Graphical Abstract: (Figure presented.)
Details
Original language | English |
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Pages (from-to) | 1731-1759 |
Number of pages | 29 |
Journal | Diabetologia |
Volume | 67 |
Issue number | 9 |
Publication status | Published - Sept 2024 |
Peer-reviewed | Yes |
External IDs
PubMed | 38910151 |
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ORCID | /0000-0002-8704-4713/work/171553159 |
Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- Autoantibodies, Glucose monitoring, Prevention, Type 1 diabetes