5-HTT genotype and inertia of negative affect in adolescents and young adults from the general population

Research output: Contribution to journalResearch articleContributedpeer-review



The study aims to replicate the previous found association of 5-HTTLPR and inertia of negative affect in daily life of adolescents and young adults. Data of 877 adolescents (aged 14-21 years) of the Behavior and Mind Health (BeMIND) study (epidemiological cohort study, Dresden, Germany) were genotyped for 5-HTTLPR/rs25531, grouped into SS/SL G/SL A/L GL A/L GL G vs. L AL A, and provided ratings on negative affect items, depression and anxiety (Patient-Reported Outcomes Measurement Information System) eight times a day over 4 days. Multilevel regression models did not reveal an association of 5-HTTLPR genotype and inertia of negative affect, nor associations with inertia of anxiety or depression. Inertia of negative affect seems not to be a psychological mechanism through which 5-HTTLPR acts on psychopathology.


Original languageEnglish
Article number415
Pages (from-to)343-351
Number of pages9
JournalJournal of Neural Transmission
Issue number3
Early online date22 Mar 2022
Publication statusPublished - Mar 2022

External IDs

Scopus 85127164059
PubMed 35246765
WOS 000764468100002
unpaywall 10.1007/s00702-022-02459-8
Mendeley 1e97374c-19e5-3216-8fb9-402dbddf0b84


Research priority areas of TU Dresden

DFG Classification of Subject Areas according to Review Boards

Sustainable Development Goals


  • Adolescent, Anxiety Disorders/genetics, Cohort Studies, Genotype, Humans, Serotonin Plasma Membrane Transport Proteins/genetics, Young Adult, Emotional inertia, Adolescence, 5-HTTLPR, Negative affect

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