Neural correlates of emotional reactivity predict response to cognitive-behavioral therapy in obsessive-compulsive disorder

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Sandra Paul - (Autor:in)
  • Norbert Kathmann - (Autor:in)
  • Björn Elsner - (Autor:in)
  • Benedikt Reuter - (Autor:in)
  • Sven Barnow - (Autor:in)
  • Daniela Simon - (Autor:in)
  • Tanja Endrass - , Professur für Suchtforschung (Autor:in)
  • Julia Klawohn - (Autor:in)

Abstract

Background: Examining predictive biomarkers to identify individuals who will likely benefit from a specific treatment is important for the development of targeted interventions. The late positive potential (LPP) is a neural marker of attention and elaborated stimulus processing, and increased LPP responses to negative stimuli are characteristic of pathological anxiety. The present study investigated whether LPP reactivity would prospectively predict response to cognitive-behavioral therapy (CBT), the first-line treatment for obsessive-compulsive disorder (OCD). Methods: To this end, the LPP in response to negative as compared to neutral pictures was examined in 45 patients with OCD, who underwent CBT in a naturalistic outpatient setting. LPP amplitudes were used as predictors of symptom reduction after CBT. Results: We found that higher LPP amplitudes to negative relative to neutral stimuli were predictive of lower self-reported OCD symptoms after completion of CBT, controlling for pre-treatment symptoms. Further, LPP reactivity was negatively correlated with self-reported habitual use of suppression in everyday life. Limitations: Some participants had already begun treatment at the time of study participation. Overall, results need further replication in larger samples and standardized therapy settings. Conclusions: The current findings suggest that patients with increased emotional reactivity benefit more from CBT, possibly through less avoidance of anxiety-provoking stimuli during exposure with response prevention, a crucial component in CBT for OCD. Although its clinical utility still needs to be evaluated further, the LPP constitutes a promising candidate as a prognostic marker for CBT response in OCD.

Details

OriginalspracheEnglisch
Seiten (von - bis)398-406
Seitenumfang9
FachzeitschriftJournal of Affective Disorders
Jahrgang2022
Ausgabenummer308
PublikationsstatusVeröffentlicht - 1 Juli 2022
Peer-Review-StatusJa

Externe IDs

Scopus 85129021770
WOS 000795943800002
Mendeley 365afa56-e8f4-3ebe-8ff7-f1af70387bc5
unpaywall 10.1016/j.jad.2022.04.024

Schlagworte

Forschungsprofillinien der TU Dresden

Fächergruppen, Lehr- und Forschungsbereiche, Fachgebiete nach Destatis

Ziele für nachhaltige Entwicklung