A 28-year-old man underwent FDG-PET/CT for Hodgkin lymphoma restaging after 6 cycles of BEACOPP chemotherapy. He had recently been diagnosed with herpes zoster, treated with antivirals, presenting with a painful rash on the right lower flank. The FDG PET scan revealed high focal FDG uptake in the right 11th spinal nerve ganglion and moderate diffuse uptake in the rash area. A follow-up scan after 10 weeks showed a complete regression of both findings. To the best of our knowledge, this is the first reported case of marked FDG-avid spinal ganglion indicating active ganglioneuritis and dermal herpes zoster, with complete regression on follow-up.